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KMID : 1059520140580050445
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Journal of the Korean Chemical Society
2014 Volume.58 No. 5 p.445 ~ p.449
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One-Pot and Green Procedure for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using ZnO Nanoparticles as a Solid Acid Catalyst
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Hassanpour Akbar
Abolhasan Jafar
Khanmiri Rahim Hosseinzadeh
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Abstract
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A convenient and efficient method has been developed for the one-pot synthesis of dihydropyrimidinones (DHPMs) compounds. Dihydropyrimidinone derivatives were synthesized in good yields using ethyl acetoacetate, aldehyde (aromatic and aliphatic) and urea or thiourea in the presence of ZnO nanoparticles as a catalyst in H2O as solvent at 80 oC. This green chemistry procedure applied to the Biginelli reaction using ZnO nanoparticles as catalyst and illustrated as a rapid preparation of DHPMs in water as solvent. The products were identified by physical data (mp) by comparison with those reported in the literatures.
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KEYWORD
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Biginelli reaction, Multicomponent reaction, ZnO nanoparticles, Dihydropyrimidinone
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